EPR Instrumentation: the Latest and the Greatest (Chair: Balaraman Kalyanaraman, Medical College of Wisconsin)

• Rapid Scan EPR (Gareth Eaton, University of Denver)
• Frequency Modulation EPR Spectroscopy from L- to W-band (Wojciech Froncisz, Jagiellonian University, Krakow, Poland)
• Experiments at Low Microwave Frequencies  (James Hyde, Medical College of Wisconsin)
• ESR Studies of Dynamics and Structure of Membranes and Proteins at ACERT  (Jack Freed, Cornell University)

Protein Structure and Dynamics by Pulsed EPR  (Chair: Candice Klug, Medical College of Wisconsin)

• New Insights into the Structure and Dynamics of the Ca2+ Binding Domain of the Cardiac Na+/Ca2+ Exchanger Determined by Site Directed Spin Labeling  (Al Beth, Vanderbilt University)
• All in the Arms of EcoRI: Clues into Protein-DNA Specificity Determinants by Pulsed ESR Distance Measurements   (Sunil Saxena, University of Pittsburgh)
• Spin Label Geometries and Protein Flexibility from DEER constraints  (Christian Altenbach, UCLA)
• Revealing Conformational Exchange in Spin Labeled Proteins (Wayne Hubbell, UCLA)

In Vivo EPR Spectroscopy and Imaging  (Chair: Harold Swartz, Dartmouth Medical School)  Dedicated to Ted Walczak

• EPR as a Noninvasive Tool to Study the Tumor Micro-environment  (Bernard Gallez, Universite Catholique de Louvain, Brussels, Belgium)
• EPR in the Field of Drug Delivery  (Karsten Mader, Martin-Luther-University of Halle)
• EPR-guided Oxygen Therapy in Ischemic Stroke  (Ke Jian “Jim” Liu, University of New Mexico, Albuquerque)
• Oxygen-guided Optimization of Radiotherapeutic Efficacy for Gliomas using Multi-site EPR Oximetry  (Nadeem Khan, Dartmouth Medical School)
• EPR Imaging of Oxygen  (Howard Halpern, University of Chicago)
• Clinical EPR:  Challenges and Progress  (Harold Swartz, Dartmouth Medical School)
• Innovative Resonators for EPR/NMR Co-imaging  (Jay Zweier, Davis Heart & Lung Research Institute)

EPR and Spin Trapping in Redox Biology  (Chairs: Neil Hogg, Medical College of Wisconsin and Jeannette Vasquez-Vivar, Medical College of Wisconsin)

• Spin Trapping Studies with Peroxiredoxin-null Yeasts  (Ohara Augusto, Instituto de Quimica, Sao Paulo, Brazil)
• EPR Tracking of Superoxide in Biological Milieu (Paul Tordo, Universites d’Aix-Marseille)
• EPR Tracking of Superoxide in Biological Milieu (Paul Tordo, Universites d’Aix-Marseille)
• Tracking Radicals in Biological Polymers...Searching for the Smoking Gun (Michael Davies, Heart Research Institute, Sydney, Australia)
• S-Nitrosothiol Formation: Radical and Non-radical Pathways (Neil Hogg, Medical College of Wisconsin)
• EPR Tracking of Superoxide in Biological Milieu  (Paul Tordo, Universites d’Aix-Marseille)
• Superoxide from NOS Uncoupling (Jeannette Vasquez-Vivar, Medical College of Wisconsin)

Free Radicals in Rare Diseases  (Chair: Maria Kadiiska, NIEHS)

• Possible Allergic Reactions to (Bi)sulfite:  Initiated Oxidation by Eozinophil Peroxidase  (Kalina Ranguelova, NIEHS)
• Peroxidative Metabolism of Beta(2)-agonists Salbutamol and Fenoterol and their Analogues:  Mechanisms that affect Control of Bronchospasm and Asthma Exacerbation  (Kristof Reszka, University of Cincinnati)
• Possible Involvement of Free Radical Metabolites in the Etiology of Drug-Induced Agranulocytosis  (Arno Siraki, University of Alberta)
• In Vivo Spin-Trapping by ESR:  Lipid-Derived Free Radical Production in Superantigen-induced Interstitial Pneumonia of Immunocompromised Mice  (Maria Kadiiska, NIEHS)
• Oxidant-Antioxidant Interactions during Trypanosoma Cruzi Invasion to Macrophages:  Implications for Chagas Disease  (Rafael Radi, Universidad de la Republica, Montevideo, Uruguay)
• In vivo Molecular Imaging of Protein Radicals in Rare Diseases (Rheal Towner, Oklahoma Medical Research Foundation)

  
Spin Trap/Spin Label Synthesis  (Chair: Micael Hardy, Universites d’Aix-Marseille)

• New Spin Probes for EPR Measurements of pH and ROS (Igor Grigoriev, Novosibirsk Institute of Organic Chemistry, Russia)
• Design and Development of Spin Traps:  Towards Detection of Superoxide in Biological Media  (Micael Hardy, Universites d’Aix-Marseille)
• Synthesis and New Applications of Nitroxides (Joy Joseph, Medical College of Wisconsin)
• Multifunctional in Vivo EPR using Nitroxyl and Trityl Radicals  (Valery Khramtsov, Davis Heart & Lung Research Institute)

Spin Labeling in Membranes  (Chair: W. Karol Subczynski, Medical College of Wisconsin)

• Physical Properties of Lipid Bilayers using Spin Labeling EPR  (W. Karol Subczynski, Medical College of Wisconsin)
• Electrostatic Landscape of Membrane Proteins and Transmembrane Dielectric Constant Gradients by EPR of pH-sensitive Nitroxides    (Alex Smirnov, North Carolina State University, Raleigh)
• Dynamics of Antimicrobial Peptide-Membrane Interactions  (Jimmy Feix, Medical College of Wisconsin)

In Vivo Oximetry and Redox Imaging  (Chair: Hideo Utsumi, Kyushu University, Fukuoka, Japan)

• Magnetic Resonance Imaging of Tumor Physiology and Metabolic Profile (Murali Cherukuri, NCI)
• EPR Oximetry: New Probes and Opportunities for Clinical Applications  (Periannan Kuppusamy, Ohio State University)
• Probes for Animal Models (Hideo Utsumi, Kyushu University, Fukuoka, Japan)

Novel Actions and Reactions of Quinones  (Chair: Tadeusz Sarna, Jageillonian University, Krakow, Poland)

• Detection and Identification of a Novel Carbon-Centered Quinone Ketoxy Radical during Metal-Independent Decomposition of Hydroperoxides by Halogenated Quinones  (Ben-Zhan Zhu, Chinese Academy of Sciences)
• Some Newly Discovered Chemistry of Quinones, Semi-quinones, and Hydroquinones: New Routes to Formation of ROS and Detoxification of PCB’s  (Garry Buettner, University of Iowa, Iowa City)
• Role of Melanin Quinone Groups in the Generation and Scavenging of Reactive Oxygen Species  (Tadeusz Sarna, Jageillonian University, Krakow, Poland)

EPR Techniques in Metalloproteins  (Chair: Sandra Eaton, University of Denver)

• Impact of Mutations on the Iron-sulfur cluster of ETF-QO (Sandra Eaton, University of Denver)
• Combining High-field EPR with Site-directed NO Spin Labeling Reveals Unique Information on Protein Structure and Local Micro-environment  (Klaus Moebius, Free University Berlin, Germany)
• Multifrequency EPR of Cupric Sites: Four Coordinate, Three Coordinate, and Free Radical Like Sites  (William Antholine, Medical College of Wisconsin)
• Rapid-Freeze-Quench EPR: What, Why, and How (Brian Bennett, Medical College of Wisconsin)

EPR Dosimetry  (Chair:  Harold Swartz, Dartmouth Medical School)

• Overview and Progress towards Field Deployment  (Benjamin Williams, Dartmouth Medical School)
• Incorporation of EPR Dosimetry into the Emergency Response System  (Ann Flood,  Dartmouth Medical School and R. Javier Nicolalde, Dartmouth Medical School )
• Development of Resonators for In Vivo EPR Imaging (Hiroshi Hirata, Hokkaido University, Sapporo, Japan)
• EPR Dosimetry Based on Fingernail Clippings  (Steven Swarts, University of Rochester, New York)

EPR Simulations  (Chair: Sushil Misra, Concordia University, Quebec, Canada)

• Rapid Development of EPR Resonators using Finite-Element Modeling  (Jason Sidabras, Medical College of Wisconsin)
• Evolution of Spectral Interpretation – From Spin Systems to Molecular Structure and Beyond (Graeme Hanson, University of Queensland, Brisbane, Australia)
• Simulation of Slow-motion CW EPR Spectrum using Stochastic Liouville Equation for an Electron Spin Coupled to Two Nuclei with Arbitrary Spins  (Sushil Misra, Concordia University, Quebec, Canada)

Spin Traps and Nitroxides in Translational Research  (Chair: Marcos Lopez, Medical College of Wisconsin)

• Observations on the Biomedical Therapeutic Potential of PBN-Nitrones  (Robert Floyd, Oklahoma Medical Research Foundation)
• Use of Nitroxide Antioxidants in Cancer Treatment and Prevention  (James Mitchell, NCI)           

Closing Remarks  (Lawrence Berliner, University of Denver)